Dietary Prebiotics can improve sleep and prevent the fight against stress by affecting intestinal bacteria: studies. Dietary Prebiotics can improve sleep and increase the flexibility of stress by affecting intestinal bacteria and metabolites (biologically active molecules), according to a new study in mice published in scientific reports.
Ingestion of prebiotic diets improves negative NREM sleep, promotes rebound of REM sleep after exposure to stress and prevents stress-induced reductions in intestinal microbial alpha diversity. Image of Sabrina Ripke. Most people are familiar with probiotics. The friendly bacteria present in fermented foods such as yogurt and sauerkraut.
Ingestion of a prebiotic diet improves negative NREM sleep, promoting the rebound of REM sleep after exposure to stress and inhibits stress-induced reductions in intestinal microbial alpha diversity. Image by Sabrina Ripke Recently, scientists have been interested in prebiotics, dietary compounds that humans cannot digest.
But that serve as trunks of our microbiome or the bacteria that live within us. While not all fibers are prebiotic, many fibrous foods such as leeks, artichokes, onions and certain whole grains are rich in them. Postdoctoral researcher in the Department of Integrative Physiology at the University of Colorado Boulder, Drs. Robert Thompson said:
The biggest path here is that this type of fiber is not just to accumulate feces and pass through the digestive system. It’s creating insects that live in our stomachs and forming a symbiotic relationship with us that has powerful effects on our brain and behavior. For the study, Drs. Thompson and his colleagues began juvenile male mice with prebiotics in standard chow or chow and tracked a series of physiological measures before and after the mice were stressed.
As reported in a previous study by the team, those with a prebiotic diet spent more time in a non-restorative sleep of rapid eye movement (NREM). After stress, they spent more time in rapid eye movements (REM). Which is considered important for overcoming stress. While mice that eat normal food had observed natural body temperature fluctuations and a decrease in the healthy diversity of their gut microbiomes after stress.
Those fed with prebiotics were cushioned by these effects. The new study sheds light on how prebiotics can relieve bust stress. We know that this combination of dietary fiber helps strengthen stress and promote good sleep and protects the intestinal microorganism from disruption, said Professor Monica Fleischner, director of the Stress Physiology Laboratory at the University of Colorado Boulder.
With this new study, we wanted to try to identify the signal. The researchers measured the metabolites, using a technique called mass spectrometry to analyze stool samples from mice. They discovered that mice in the prebiotic diet had a different ‘metabolism’, or metabolite composition. It was high in dozens of them, including fatty acids, sugars and steroids.
Which can affect behavior through the intestine-brain signaling pathway. It looked different even after stress. For example, mice with the standard Chow diet saw dramatic peaks in the alloprenanolone precursors and ketone steroids, presumably metabolites that disturb sleep, while those in the prebiotic diet did not see that peak. Our results reveal new signals that come from intestinal microbes that can regulate the physiology of stress and sleep, said Professor Fleshner.
While prebiotic dietary fiber is certainly healthy, it is unclear whether loading only rich foods can promote sleep. The rats were fed very high doses of four specific prebiotics. Which include: galactuligosaccharides, which are present in lentils and cabbage; Polydextrose (PDX) is an FDA-approved food additive that is often used as a sweetener; Lactoferrin is found in breast milk.
And spherical proteins rich in milk fats, abundant in dairy products. You can probably eat a lot of lentils and cabbage to see any effect, said Dr. Thompson said. Prebiotic supplements are already abundant on the shelves of health food stores. But he also said that it is too early to say whether a supplement or a medicine containing such compounds will be safe and effective for everyone. Depending on their microbial composition, different people may react differently.
These are powerful molecules with real neuroactive effects and people should be a little careful.